Format

Send to

Choose Destination
Maturitas. 2018 Nov;117:57-63. doi: 10.1016/j.maturitas.2018.09.006. Epub 2018 Sep 29.

Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study.

Author information

1
Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid (UAM), C/ Arzobispo Morcillo 4, 28029, Madrid, Spain.
2
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Faculty of Medicine, University of Alcalá, Campus Científico-Tecnológico, Crta. de Madrid-Barcelona, Km. 33,600, 28871, Alcalá de Henares, Madrid, Spain.
3
Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, Av. Gran Vía s/n km 2,7, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
4
General Directorate Public Health, and FISABIO, Av. de Catalunya 21, 46020, Valencia, Spain.
5
Balearic Islands Breast Cancer Screening Program, Health Promotion for Women and Childhood, General Directorate Public Health and Participation, Regional Authority of Health and Consumer Affairs, C/Jesús, 40 Pabellón II, 07010, Palma, Balearic Islands, Spain.
6
Castile-Leon Breast Cancer Screening Program, General Directorate Public Health SACYL, Av. Sierra de Atapuerca s/n, 09002, Burgos, Spain.
7
Aragon Breast Cancer Screening Program, Health Service of Aragon, Av. Cesar Augusto 11, 50004, Zaragoza, Spain.
8
Galicia Breast Cancer Screening Program, Regional Authority of Health, Galicia Regional Government, C/ Duran Loriga 3, 15003, Corunna, Spain.
9
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Early Detection Section, Public and Labor Health Institute of Navarra, C/ Leyre, 15, 31003, Pamplona, Spain; Healthcare Research Institute of Navarre (IdiSNA), C/ de Irunlarrea 3, 31008, Pamplona, Spain.
10
Institute of Computer Technology, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
11
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Nutritional Epidemiology Unit, University Miguel Hernandez, ISABIAL-FISABIO, Ctra. Nacional 332 s/n, 03550, Sant Joan D'alacant, Alicante, Spain.
12
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Av. Monforte de Lemos 5, 28029, Madrid, Spain.
13
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Av. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Av. Monforte de Lemos 5, 28029, Madrid, Spain. Electronic address: vicarvajal@isciii.es.

Abstract

OBJECTIVES:

Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.

STUDY DESIGN:

We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.

MAIN OUTCOME MEASURE:

Mammographic density.

RESULTS:

Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.

CONCLUSIONS:

This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.

KEYWORDS:

Basal metabolic rate; Breast density; Caloric intake; Calories; Energy intake

PMID:
30314562
DOI:
10.1016/j.maturitas.2018.09.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center