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Seizure. 2018 Nov;62:91-94. doi: 10.1016/j.seizure.2018.09.001. Epub 2018 Sep 14.

Estimation of seizures prevalence in ischemic strokes after thrombolytic therapy.

Author information

1
Sackler Medical School, Tel-Aviv University, Israel.
2
Neurological department, Kaplan Medical Center, Rechovot, Israel; Hebrew university, Jerusalem, Israel.
3
Neurological department, Kaplan Medical Center, Rechovot, Israel.
4
Management department, Kaplan Medical Center, Rechovot, Israel.
5
Neurological department, Kaplan Medical Center, Rechovot, Israel. Electronic address: andail@clalit.org.il.

Abstract

PURPOSE:

Post stroke seizures are a complication that occur in 5-20% of acute ischemic stroke (AIS) patients, cause a reduction in quality of life and a greater burden on the health system. There is not enough data regarding an association between today's standard of care treatment in AIS: recombinant tissue plasminogen activator (r-tPA) and the risk for post stroke seizures. Our aim in this work is to reveal such a connection.

METHOD:

A non-randomized retrospective cohort-controlled study of 234 patients, who were hospitalized with acute ischemic stroke at Kaplan Medical Center in the years 2009-2015 and were divided into two different treatment groups: r-tPA and antiaggregant therapy(n = 141) and antiaggregant therapy only (n = 95) was conducted by us. Information regarding demographics, medical history, nature of the event, including NIHSS values on admission, discharge, and post stroke seizures, were obtained for each group. Follow-up was done for one year.

RESULTS:

During the year of follow-up, 19 patients (8.1%) of the overall cohort, developed seizures: 12 of them (12.6%) belonged to the control group and 7 (5%) to the study group p < 0.05). Results showed a decrease in the risk for developing seizure when treated with r-tpA, comparing to antiaggregants (odds ratio = 0.64).

CONCLUSION:

This study suggests there is an association between r-tPA treatment and reduction of the risk for post stroke seizures.

KEYWORDS:

Ischemic stroke; Post-stroke seizures; Thrombolytic therapy

PMID:
30312935
DOI:
10.1016/j.seizure.2018.09.001
[Indexed for MEDLINE]

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