Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

J Allergy Clin Immunol. 2019 Feb;143(2):778-781.e5. doi: 10.1016/j.jaci.2018.09.020. Epub 2018 Oct 10.

Authors

Yapei Huang¹, Yan Xie¹, Haihong Jiang¹, Peter W Abel¹, Reynold A Panettieri Jr², Thomas B Casale³, Yaping Tu⁴

Affiliations

¹ Department of Pharmacology, Creighton University School of Medicine, Omaha, Neb.
² Rutgers Institute for Translational Medicine and Science, Rutgers Biomedical and Health Sciences, Rutgers University, New Brunswick, NJ.
³ Department of Internal Medicine, University of South Florida School of Medicine, Tampa, Fla. Electronic address: tbcasale@health.usf.edu.
⁴ Department of Pharmacology, Creighton University School of Medicine, Omaha, Neb. Electronic address: Yapingtu@creighton.edu.

PMID: 30312708
DOI: 10.1016/j.jaci.2018.09.020

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Airway Obstruction / genetics
Airway Obstruction / metabolism*
Airway Remodeling / genetics
Asthma / genetics
Asthma / metabolism*
Cells, Cultured
Guanine Nucleotide Exchange Factors / genetics
Guanine Nucleotide Exchange Factors / metabolism*
Humans
Hyperplasia
Myocytes, Smooth Muscle / metabolism*
Myocytes, Smooth Muscle / pathology
Neoplasm Metastasis / genetics
Receptor, Platelet-Derived Growth Factor beta / metabolism
Respiratory System / pathology*
Up-Regulation
rac1 GTP-Binding Protein / genetics
rac1 GTP-Binding Protein / metabolism*

Substances

Guanine Nucleotide Exchange Factors
PREX1 protein, human
PDGFRB protein, human
Receptor, Platelet-Derived Growth Factor beta
rac1 GTP-Binding Protein

Grants and funding