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Brain Struct Funct. 2019 Jan;224(1):253-262. doi: 10.1007/s00429-018-1773-3. Epub 2018 Oct 11.

The SLC6A3 3'-UTR VNTR and intron 8 VNTR polymorphisms association in the time estimation.

Author information

1
Neuro-innovation Technology and Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião no. 2819, Nossa Sra. de Fátima, Parnaíba, PI, CEP: 64202-020, Brazil. victormarinhophb@hotmail.com.
2
Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil. victormarinhophb@hotmail.com.
3
The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil. victormarinhophb@hotmail.com.
4
Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil.
5
The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.
6
Neuro-innovation Technology and Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião no. 2819, Nossa Sra. de Fátima, Parnaíba, PI, CEP: 64202-020, Brazil.
7
Brain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
8
Department of Biology, Camden County College, Blackwood, NJ, USA.
9
Brain Mapping and Functionality Laboratory, Federal University of Piauí, Parnaíba, Brazil.

Abstract

OBJECTIVE:

The present study investigated the association of 3'-UTR VNTR and intron 8 VNTR polymorphisms with a time estimation task performance.

MATERIALS AND METHODS:

One hundred and eight men in a Brazilian Northeast population (18-32 years old) participated in the experiment. The 3'-UTR VNTR and intron 8 VNTR polymorphisms were associated alone and combined to absolute error (AE) and relative error (RE) in a time estimation task (target duration: 1 s, 4 s, 7 s and 9 s).

RESULTS:

We found an association of the behavioral variable with intron 8 VNTR for the time intervals of 1 s and 9 s (p < 0.001) and polymorphisms combinatorial effect for 1 s (p ≤ 0.05).

CONCLUSION:

The intron 8 VNTR polymorphism and the combinatorial effect can modulate the time estimate in the domain of supra seconds, and thus our study indicates a role of the dopamine transporter in the neurobiological areas related to the time intervals judgment.

KEYWORDS:

Dopamine; SLC6A3 3′-UTR VNTR; SLC6A3 intron 8 VNTR; Time estimation; Time perception

PMID:
30310975
DOI:
10.1007/s00429-018-1773-3

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