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BMC Res Notes. 2018 Oct 11;11(1):720. doi: 10.1186/s13104-018-3819-2.

Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study.

Collaborators (235)

Pugh R, Battle C, Lyons R, Morgan P, Hobrok M, Otahal I, Havalda P, Hamlyn V, Macchiavello L, Jones R, Minik O, Morgan P, Ellis G, Brown C, Littler C, Campbell A, George D, Subbe C, Hall JE, Szoke S, Self R, Gunter U, Lundin RM, Alsaeed M, Williams H, Ayob A, Farzana N, Parida S, Lawson D, Mazur M, D'Souza L, Ponting B, Lau T, Kerrigan R, Morgan L, Vindla R, Zeicu C, James B, Ariff AA, Azzlan WBW, Collins C, Wickens E, Norbee A, Zulkefli A, Haddock T, Thomas M, Lee M, Dandawate A, Shayan-Arani H, Taylor E, Kyriakides O, Price R, Mackey FH, Haines E, Chun S, Roberts C, Waller A, Heekin L, Wang K, Church R, Patel S, Broderick M, Whillis H, Hathaway DC, Yildirim E, Atkins C, Mounce AG, Ramjeeawon A, Mtunzi N, Soppitt D, Hale J, Wellington J, Ross RB, Lis D, Stovold S, Vickery S, Jones N, O'Donnell A, Cuthbert M, Eghosa O, Karim M, Williams L, Tucker L, Downs T, MacNaught A, Balachandran S, Shipley A, Kent JL, Roberts T, Tilley S, Davies B, Withers E, Parmar K, Webber L, Grother T, Smith H, Watson R, Hoyle N, El Alaoui RC, Marei O, Kirby E, Gilfedder A, Maw L, O'Connor S, Rogers A, Tan ZX, Chantrill C, Robertson A, Foulkes J, Khanam R, John J, Sutherland I, Meehan SH, Metezai H, Dawson H, Baxendale E, Khan K, Myat P, Forrester A, Moore O, Lim HJ, Owen A, Hussain F, Allybocus NB, Sethi M, Asim U, Boggon E, Alkurd I, Lawrence G, Brown J, Thomas LH, Murphy E, Lambert E, Guilford J, Payne B, Almulaifi M, Poacher A, Ganesananthan S, Tanatova S, Kew J, Clark ME, Hannay E, Godsafe O, Houghton C, Lavric F, Mallinson R, Chan HMP, Ang E, McSwiney N, Lim YY, Lee ZX, Kulikouskaya S, Zulkifli N, Lim S, Xin L, Chandy T, Taufik A, Cochrane J, Davies S, Willis S, Lynch J, Heng SY, Cooper A, von der Pahlen HG, Talbot I, Roberts RG, Smith JS, Sweeney A, Roberts C, McNulty P, Walters E, Sinnerton R, Tanner B, Cunningham-Walker B, Spooner C, Kiran A, Nadeem N, Unadkat V, Hui JNC, Sparey E, Li D, Smith J, Corrin I, Waring H, Khan A, Baker E, Amjad MY, Cynan M, Hay I, Russell C, Davies J, Parsonson R, Arunthavarajah A, Nicholas J, Harris A, Burnett T, Gowar JR, DeFriend S, Jones H, Maliki NAB, Zimmerman M, Webber J, Phillips R, McCarthy L, Wirt L, Hubbard E, Evans E, Davis LJ, Davies LW, Sanders-Crook L, Dhadda A, Logue G, Jones I, Urazbayeva A, Hanif NHA, Ying YK, Coleclough A, Higgins E, Ng TG, Booth S, Vignarajah N, Chamberlain T, Zhao D, Tantirige NN, Watts J, Prideaux A, Tee A, Hook A, Mounce A, Eccles E, Ramesh K, Bausor L, Handley A, Paddock R, Banerjee L.

Author information

1
Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Heath Park Campus, Cardiff, CF14 4XN, UK.
2
Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Heath Park Campus, Cardiff, CF14 4XN, UK. szakmanyt1@cardiff.ac.uk.
3
Anaesthetic Directorate, Aneurin Bevan University Health Board, Royal Gwent Hospital, Cardiff Road, Newport, Gwent, NP20 2UB, UK. szakmanyt1@cardiff.ac.uk.

Abstract

OBJECTIVE:

Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments.

RESULTS:

839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%).

KEYWORDS:

Critical care; Frailty; Mortality; Sepsis

PMID:
30309393
PMCID:
PMC6182791
DOI:
10.1186/s13104-018-3819-2
[Indexed for MEDLINE]
Free PMC Article

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