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Curr Opin Chem Biol. 2019 Feb;48:19-25. doi: 10.1016/j.cbpa.2018.09.016. Epub 2018 Oct 9.

Understanding molecular mechanisms of disease through spatial proteomics.

Author information

1
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
2
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States. Electronic address: jyates@scripps.edu.

Abstract

Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.

PMID:
30308467
PMCID:
PMC6435883
[Available on 2020-02-01]
DOI:
10.1016/j.cbpa.2018.09.016

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