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Clin Imaging. 2018 Oct 4;53:17-24. doi: 10.1016/j.clinimag.2018.09.021. [Epub ahead of print]

Pretreatment quantitative 18F-FDG PET/CT parameters as a predictor of survival in adenoid cystic carcinoma of the salivary glands.

Author information

1
Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address: genct003@umn.edu.
2
Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address: keremozturk@uludag.edu.tr.
3
Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address: ykksel@umn.edu.
4
Department of Pathology and Laboratory Medicine, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address: lif@umn.edu.
5
Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address: cayci001@umn.edu.

Abstract

PURPOSE:

The aim of this study was to determine the unique prognostic value of quantitative 18F-FDG PET/CT parameters to assess progression-free survival (PFS), distant metastasis-free survival (DMFS), and overall survival (OS) in patients with salivary gland adenoid cystic carcinoma (ACC).

METHODS:

We performed a retrospective study including 23 patients (15 men, 8 women; median age, 58 years; range, 21-91 years) with salivary gland ACC between January 2009 and October 2017 who underwent 18F-FDG PET/CT scan prior to treatment. Maximum, mean, peak, tumor-to-mediastinal blood pool and tumor-to-liver standardized uptake values (SUVmax, SUVmean, SUVpeak, SUVratio[med] and SUVratio[liver]), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from 18F-FDG PET/CT. The prognostic value of quantitative 18F-FDG PET/CT parameters and other clinicopathological variables were evaluated utilizing the Cox proportional regression analysis.

RESULTS:

The 3-year and 5-year OS for all the patients were 90.9%, and 62.3%, respectively. Log rank test determined that the SUVratio[med], SUVratio[liver], MTV and TLG were predictive factors of DMFS, PFS, and OS (p < 0.05), furthermore, SUVmax, minor salivary gland tumors and DM at initial diagnosis (M1 stage) were predictor for PFS; M1 stage and overall stage 3-4 predicted DMFS (all p < 0.05). Cox regression analyses confirmed that the higher SUVratio[med], SUVratio[liver], MTV, and TLG values predicted DMFS, PFS and OS independently, whereas SUVmax was an independent predictor of only PFS (p < 0.05).

CONCLUSIONS:

The pretreatment metabolic 18F-FDG PET/CT parameters may reflect tumor aggressiveness in patients with salivary gland ACC and may potentially be utilized as a prognostic biomarker.

KEYWORDS:

(18)F-FDG PET/CT; Adenoid cystic carcinoma; Overall survival; Prognosis; Salivary gland cancer

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