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Farmakol Toksikol. 1987 Jan-Feb;50(1):5-8.

[Comparative study of the analgesic, sedative and myorelaxant effects of GABA-positive preparations].

[Article in Russian]


It was shown in experiments on rats that the analgesic effect of GABA-positive drugs is followed by sedative and myorelaxant manifestations, however there is no direct relationship between the effects. Bicuculline significantly attenuates analgesia induced by THIP, gamma-acetylenic-GABA and depakin in the test of vocalization but enhances their analgesic activity in the tail-flick test. The involvement of individual subtypes of GABA receptors in mediation of analgesic and general depressant effects of GABA-positive drugs was discussed.

[Indexed for MEDLINE]

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