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Microb Genom. 2018 Oct;4(10). doi: 10.1099/mgen.0.000227. Epub 2018 Oct 11.

Genomic epidemiology of clinical Campylobacter spp. at a single health trust site.

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1​College of Medical and Dental Sciences, Institute of Microbiology and Infection, University of Birmingham, Birmingham, West Midlands, UK.
2​University of Bath, Bath, UK.
3​University of Nottingham, Nottingham, UK.
4​Nottingham University Hospitals NHS Trust, Nottingham, UK.
5​University of Wolverhampton, Wolverhampton, UK.


Campylobacter is the leading cause of bacterial enteritis in the developed world, and infections with the organism are largely sporadic in nature. Links between sporadic cases have not been established, with the majority of infections thought to be caused by genetically distinct isolates. Using a read-mapping approach, 158 clinical isolates collected during 2014 from the greater Nottinghamshire area were analysed to assess the local population structure and investigate potential case linkages between sporadic cases of campylobacteriosis. Four instances (2.5 %) of case linkage were observed across the dataset. This study demonstrates that case linkage does occur between sporadic Campylobacter infections, and provides evidence that a dual multi-locus sequence typing/within-lineage single nucleotide polymorphism typing approach to Campylobacter genomic epidemiology provides a benefit to public-health investigations.


Campylobacter; United Kingdom; WGS; clinical; epidemiology; genomics

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