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Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1;50(11):1075-1084. doi: 10.1093/abbs/gmy110.

SNX6 predicts poor prognosis and contributes to the metastasis of pancreatic cancer cells via activating epithelial-mesenchymal transition.

Hu P1,2,3, Liang Y1,2,3, Hu Q2,4, Wang H1,2,3, Cai Z1,2,3, He J1,2,3, Cai J1,2,3, Liu M1,2,3, Qin Y2,4, Yu X2,4, Jiang C1,2,3, Zhang B2,4, Wang W1,2,3.

Author information

1
Department of General Surgery, Huadong Hospital, Fudan University, Shanghai, China.
2
Shanghai Pancreatic Cancer Institute, Shanghai, China.
3
Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China.
4
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Abstract

Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate around 6%. Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rate. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of pancreatic cancer. In the present study, by using the Cancer Genome Atlas (TCGA) dataset analysis, we demonstrated that sorting nexin 6 (SNX6) serves as a biomarker for predicting prognosis of pancreatic cancer. In vitro studies demonstrated that silencing of SNX6 expression reduced cell proliferation, colony formation, invasion, and metastasis. Higher level of SNX6 helps maintain the mesenchymal properties, which renders migration and invasive capacities to pancreatic cancer cells. Moreover, in the process of TGF-β-induced epithelial to mesenchymal transition (EMT), the expression level of SNX6 was increased, and silencing of SNX6 expression could inhibit the TGF-β-induced EMT program. These results collectively uncovered a novel predictive marker for pancreatic cancer and provided the possible underlying molecular mechanism.

PMID:
30307473
DOI:
10.1093/abbs/gmy110
[Indexed for MEDLINE]

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