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J Dermatolog Treat. 2018 Oct 11:1-27. doi: 10.1080/09546634.2018.1535689. [Epub ahead of print]

Real-world experience of calcipotriene and betamethasone dipropionate foam 0.005%/0.064% in the treatment of adults with psoriasis in the United States.

Author information

1
a Kaiser Permanente Los Angeles Medical Center , Los Angeles , CA , USA.
2
b LEO Pharma Inc. , Madison , NJ , USA.
3
c Keck School of Medicine at USC, University of Southern California , Los Angeles , CA , USA.

Abstract

BACKGROUND:

Clinical trials have established calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam as a well-tolerated and efficacious topical therapy for psoriasis.

METHODS:

A chart review of 24 US healthcare providers gathered real-world information (clinical characteristics and outcomes, safety, and resource utilization) for patients (≥18 years old) prescribed Cal/BD foam between January 1 and October 31, 2016, along with healthcare provider characteristics and perceptions of Cal/BD foam.

RESULTS:

Data were reported from 105 patients and 177 active psoriatic lesions. Cal/BD foam was applied once-daily; the prescription was 4 weeks for 69/177 (39%) lesions (median 4, range 1-26 weeks). Knees (n = 41; 23%) and elbows (n = 37; 20%) were the most frequently treated areas. Among 114 lesions, severity improved from "mild"/"moderate"/"severe" to "clear"/"almost clear" in 71%, and 54% had a clinically significant improvement (two-step/greater improvement) in lesion severity from baseline. Of 128 lesions with baseline itch, 90% were not itchy at the best treatment response. Most healthcare providers reported prescribing Cal/BD foam due to its overall efficacy (n = 20/23; 87%). Adverse events were reported in 1/105 patients (1%).

CONCLUSION:

Data from real clinical practice demonstrate that Cal/BD foam improves psoriasis disease severity and associated itch in patients and further extend results of clinical trials.

KEYWORDS:

Calcipotriene; betamethasone dipropionate; foam; itch; psoriasis; real-world

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