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Tissue Eng Part C Methods. 2018 Nov;24(11):628-636. doi: 10.1089/ten.TEC.2018.0151. Epub 2018 Nov 7.

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells.

Author information

1
1 Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente , Enschede, The Netherlands .
2
2 MESA+ Institute for Nanotechnology, Molecular Nanofabrication Group, University of Twente , Enschede, The Netherlands .
3
3 Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, Maastricht University , Maastricht, The Netherlands .

Abstract

This research deals with finding a proper bioengineering strategy for the creation of improved β-cell replacement therapy in type 1 diabetes. It specifically deals with the microenvironment of β-cells and its relationship to their endocrine function.

KEYWORDS:

insulin secretion; islet transplantation; type 1 diabetes; β-cell replacement therapies; β-cells

PMID:
30306836
DOI:
10.1089/ten.TEC.2018.0151

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