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Tissue Eng Part C Methods. 2018 Nov;24(11):637-644. doi: 10.1089/ten.TEC.2018.0249. Epub 2018 Nov 2.

Large-Scale Preparation of Extracellular Vesicles Enriched with Specific microRNA.

Author information

1
1 Institute for Regenerative Medicine, Wake Forest University Health Sciences , Winston-Salem, North Carolina.
2
2 Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China .
3
3 Department of Cancer Biology, Wake Forest University Health Sciences , Winston-Salem, North Carolina.

Abstract

This article describes a method for producing microRNA (miRNA)-enriched extracellular vesicles in large quantities. It enables in vivo delivery of specific miRNA for therapeutic applications.

KEYWORDS:

extracellular vesicle; large-scale production; miRNA-133a-3p; miRNA-202-5p; microRNA

PMID:
30306827
PMCID:
PMC6916128
DOI:
10.1089/ten.TEC.2018.0249
[Indexed for MEDLINE]
Free PMC Article

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