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Eye (Lond). 2019 Mar;33(3):419-427. doi: 10.1038/s41433-018-0228-7. Epub 2018 Oct 10.

Choroidal morphology and short-term outcomes of combination photodynamic therapy in polypoidal choroidal vasculopathy.

Author information

1
Department of Ophthalmology and Visual Science, Bucheon St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.
2
Department of Ophthalmology and Visual Science, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3
Department of Ophthalmology and Visual Science, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. wklee@catholic.ac.kr.

Abstract

PURPOSE:

To investigate outcomes of combined photodynamic therapy (PDT) and intravitreal bevacizumab in association with choroidal morphology in polypoidal choroidal vasculopathy (PCV).

METHOD:

Eighty-six PCV eyes (83 patients) treated with PDT in combination with intravitreal bevacizumab and followed for 1 year were evaluated. Choroidal morphological features including subfoveal choroidal thicknesses, diameter of pachyvessel, and choroidal vascularity were analyzed for association with responsiveness and recurrence.

RESULT:

Total choroid, Haller's layer, and pachyvessel were thicker in responders (n = 70) compared with non-responders (n = 16) at baseline (298 vs. 227 μm, 213 vs. 144 μm, and 276 vs. 210 μm, respectively; all P ≤ 0.001). Choroidal vascularity was significantly higher (0.68 vs 0.60, P < 0.001) and choroidal hyperpermeability was more frequent in responders (44 vs 13%, P = 0.018). Significant thinning of total choroid was observed in both responders and non-responders at 3 months after combination PDT (both P < 0.05), but the reduction was greater in responders (- 33 μm vs. - 10 μm, P = 0.036). In recurrent eyes (n = 26), increase in pachyvessel diameter and choroidal vascularity was observed at recurrence.

CONCLUSION:

Choroidal morphology including characteristic features of pachychoroid and high vascularity can serve as predictive factors for outcomes after combination PDT in eyes with PCV.

PMID:
30305706
PMCID:
PMC6460701
[Available on 2020-03-01]
DOI:
10.1038/s41433-018-0228-7

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