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J Oleo Sci. 2018;67(10):1271-1277. doi: 10.5650/jos.ess18143.

Collagen Synthesis-Promoting Effects of Andiroba Oil and its Limonoid Constituents in Normal Human Dermal Fibroblasts.

Author information

1
Pharmaceutical Research and Technology Institute.
2
Antiaging Center, Kindai University.
3
Osaka University of Pharmaceutical Sciences.

Abstract

The seed oil of andiroba (Carapa guianensis, Meliaceae) was found to promote collagen synthesis in normal human dermal fibroblasts. To characterize the active constituents of this oil, the collagen synthesis-promoting activities of 10 principal limonoid constituents, gedunin (1), 6α-acetoxygedunin (2), 7-deacetoxy-7-oxogedunin (3), 7-deacetoxy-7α-hydroxygedunin (4), andirolide H (5), 6α-hydroxygedunin (6), methyl angolensate (7), 17β-hydroxyazadiradione (8), and carapanosides C (9) and R (10), were examined. Among them, 1-4, 6, 7, and 9 were found to significantly promote collagen synthesis without cytotoxicity at the effective concentrations.

KEYWORDS:

Carapa guianensis; andiroba oil; collagen synthesis-promoting activity; gedunin; limonoid

PMID:
30305560
DOI:
10.5650/jos.ess18143
[Indexed for MEDLINE]
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