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PLoS One. 2018 Oct 10;13(10):e0204228. doi: 10.1371/journal.pone.0204228. eCollection 2018.

Characterization of gene expression changes over healthy term pregnancies.

Author information

1
Genetics and Molecular Biology Program, Emory University, Atlanta, GA, United States of America.
2
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States of America.
3
Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, United States of America.
4
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, United States of America.
5
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, United States of America.

Abstract

During pregnancy, women experience numerous physiological changes but, to date, there is limited published data that characterize accompanying changes in gene expression over pregnancy. This study sought to characterize the complexity of the transcriptome over the course of pregnancy among women with healthy pregnancies. Subjects provided a venous blood sample during early (6-15 weeks) and late (22-33 weeks) pregnancy, which was used to isolate peripheral blood mononuclear cells prior to RNA extraction. Gene expression was examined for 63 women with uncomplicated, term deliveries. We evaluated the association between weeks gestation at sample collection and expression of each transcript. Of the 16,311 transcripts evaluated, 439 changed over pregnancy after a Bonferroni correction to account for multiple comparisons. Genes whose expression increased over pregnancy were associated with oxygen transport, the immune system, and host response to bacteria. Characterization of changes in the transcriptome over the course of healthy term pregnancies may enable the identification of genes whose expression predicts complications or adverse outcomes of pregnancy.

PMID:
30303981
PMCID:
PMC6179206
DOI:
10.1371/journal.pone.0204228
[Indexed for MEDLINE]
Free PMC Article

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