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Indian J Pathol Microbiol. 2018 Oct-Dec;61(4):607-609. doi: 10.4103/IJPM.IJPM_404_17.

Keratomycosis due to Purpureocillium lilacinum: A case report from Sub-Himalayan region of Uttarakhand.

Author information

1
Department of Microbiology, Government Doon Medical College, Dehradun, Uttarakhand, India.
2
Department of Microbiology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India.
3
Department of Microbiology, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.
4
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
5
Department of Ophthalmology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India.

Abstract

The fungus Purpureocillium lilacinum previously known as Paceliomyces lilacinus is an emerging pathogen that can cause severe human infections including devastating oculomycosis. Treatment with traditional antifungals often fails, and the organism shows variable susceptibility to novel triazoles. We hereby report a case of keratomycosis caused by Pur. lilacinum in an immunocompetent male patient following trauma. The patient was successfully treated with voriconazole. The drug shows good activity against Pur. lilacinum and could be a promising therapeutic alternative to treat infections caused by this fungus, which generally shows resistance to conventional antifungal agents including novel triazoles.

KEYWORDS:

Keratitis; Paecilomyces; Purpureocillium; oculomycosis; voriconazole

PMID:
30303164
DOI:
10.4103/IJPM.IJPM_404_17
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