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Indian J Pathol Microbiol. 2018 Oct-Dec;61(4):553-556. doi: 10.4103/IJPM.IJPM_119_17.

Adult T-cell leukemia/lymphoma and acquired immunodeficiency syndrome - CD4+ T-cell malignancy in CD4+ T-cell deficient status: A paradox.

Author information

1
Department of Hematopathology, AmPath, Hyderabad, Telangana, India.
2
Department of Medicine, Sunshine Hospital, Hyderabad, Telangana, India.
3
Department of Hematopathology, Lifeline Tapadia Diagnostic Center, Hyderabad, Telangana, India.

Abstract

CD4 counts along with viral loads are important parameters in the monitoring of human immunodeficiency virus (HIV) infection. Human T-cell lymphotropic virus type I (HTLV-I) is known to be an etiological agent for adult T-cell leukemia/lymphoma (ATLL). Coinfection of HTLV-I and HIV is well known in regions with high seroprevalence, and there is no published data in the Indian scenario. We present an interesting case of occurrence of CD4+ T-cell proliferation in a known beta thalassemia major with acquired HIV seropositivity accompanied by simultaneously increasing CD4+ counts and viral loads. Further workup revealed ATLL with an underlying HTLV infection.

KEYWORDS:

Adult T-cell leukemia/lymphoma; CD4; human T-cell lymphotropic virus type I; human immunodeficiency virus; thalassemia; viral load

PMID:
30303147
DOI:
10.4103/IJPM.IJPM_119_17
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