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Sci Signal. 2018 Oct 9;11(551). pii: eaau8876. doi: 10.1126/scisignal.aau8876.

Arid5a makes the IL-17A/F-responsive pathway less arid.

Puel A1,2,3, Casanova JL4,2,3,5,6.

Author information

1
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, 75015 Paris, France. anne.puel@inserm.fr.
2
Paris Descartes University, Imagine Institute, 75015 Paris, France.
3
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.
4
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, 75015 Paris, France.
5
Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France.
6
Howard Hughes Medical Institute, New York, NY 10065, USA.

Abstract

The cytokine interleukin-17A/F (IL-17A/F) not only protects the skin and mucosae against Candida albicans infection in mice and humans but also promotes autoimmunity and autoinflammation in mice. In this issue of Science Signaling, Amatya et al report that the RNA binding protein Arid5a promotes responses to IL-17A/F through multiple mechanisms.

PMID:
30301789
DOI:
10.1126/scisignal.aau8876
[Indexed for MEDLINE]

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