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J Exp Med. 2018 Nov 5;215(11):2702-2704. doi: 10.1084/jem.20181737. Epub 2018 Oct 9.

Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities.

Author information

1
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
2
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel michal.schwartz@weizmann.ac.il.

Abstract

Immune cells patrol the brain and can support its function, but can we modulate brain-immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.

PMID:
30301785
PMCID:
PMC6219738
[Available on 2019-05-05]
DOI:
10.1084/jem.20181737

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