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Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/j.it.2018.09.003. Epub 2018 Oct 6.

Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.

Author information

1
Department of Veterinary Microbiology and Pathology, Washington State, Pullman, WA, USA. Electronic address: dana.shaw@wsu.edu.
2
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address: a.tate@vanderbilt.edu.
3
Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
4
Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
5
Division of Gastroenterology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
6
Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
7
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
8
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jpedra@som.umaryland.edu.

Abstract

Recent scientific breakthroughs have significantly expanded our understanding of arthropod vector immunity. Insights in the laboratory have demonstrated how the immune system provides resistance to infection, and in what manner innate defenses protect against a microbial assault. Less understood, however, is the effect of biotic and abiotic factors on microbial-vector interactions and the impact of the immune system on arthropod populations in nature. Furthermore, the influence of genetic plasticity on the immune response against vector-borne pathogens remains mostly elusive. Herein, we discuss evolutionary forces that shape arthropod vector immunity. We focus on resistance, pathogenicity and tolerance to infection. We posit that novel scientific paradigms should emerge when molecular immunologists and evolutionary ecologists work together.

PMID:
30301592
PMCID:
PMC6218297
[Available on 2019-11-01]
DOI:
10.1016/j.it.2018.09.003

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