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J Diet Suppl. 2018 Oct 9:1-14. doi: 10.1080/19390211.2018.1481483. [Epub ahead of print]

Cardioprotective Efficacy of Coriandrum sativum (L.) Seed Extract in Heart Failure Rats Through Modulation of Endothelin Receptors and Antioxidant Potential.

Author information

1
a Department of Physiology , Hamdard Institute of Medical Sciences and Research, Jamia Hamdard (Hamdard University) , New Delhi , India.
2
b Centre for Physiotherapy and Rehabilitation Sciences , Jamia Millia Islamia (Central University) , New Delhi , India.

Abstract

The present study aimed to evaluate the therapeutic and prophylactic potential of Coriandrum sativum extract in isoproterenol-induced heart failure (HF) in Wistar rats. Two weeks after the isoproterenol administration, rats developed severe impairment in left ventricular functions, reduced baroreflex sensitivity, and significant alteration in hemodynamic parameters and lipid profile. HF rats also exhibited enhanced lipid peroxidation and increased expression of endothelin receptors (ETA and ETB). Therapeutic and prophylactic treatment with C. sativum extract significantly (pā€‰<ā€‰.05) improved the left ventricular functions and hemodynamic parameters and increased baroreflex sensitivity. It also inhibited lipid peroxidation, improved lipid profile, and downregulated the expression of endothelin receptors. Simvastatin treatment showed a similar cardioprotective effect. Our results suggest that C. sativum extract provides significant protection from heart failure possibly due to its ability to improve left ventricular functions and baroreflex sensitivity, attenuate lipid peroxidation, and modulate the expression of endothelin receptors.

KEYWORDS:

Coriandrum sativum; baroreflex sensitivity; endothelin receptors; heart failure; left ventricular functions

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