Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis

Chem Commun (Camb). 2018 Oct 23;54(85):12093-12096. doi: 10.1039/c8cc07398h.

Abstract

A robust fluorescent probe CTPA has been rationally designed for cancer diagnosis by monitoring lipid drop (LD) polarity and number variation. With the outstanding properties of CTPA, we have shown that the diagnosis of cancer can be achieved not only at the cellular levels but also in organs and living mice for the first time.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Coumarins / chemical synthesis
  • Coumarins / chemistry*
  • Coumarins / toxicity
  • Drug Design
  • Female
  • Fluorescence
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / toxicity
  • Humans
  • Lipid Droplets / metabolism*
  • Mice, Inbred BALB C
  • Neoplasms / diagnostic imaging*
  • Optical Imaging / methods

Substances

  • Coumarins
  • Fluorescent Dyes