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Chem Commun (Camb). 2018 Oct 30;54(87):12318-12321. doi: 10.1039/c8cc06480f.

Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88.

Author information

1
Department of Biophysics, Kyoto University, Kyoto, 606-8502, Japan. tochio@mb.biophys.kyoto-u.ac.jp.

Abstract

MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

PMID:
30298869
DOI:
10.1039/c8cc06480f

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