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Vet Anaesth Analg. 2018 Nov;45(6):754-759. doi: 10.1016/j.vaa.2018.08.002. Epub 2018 Sep 5.

Effect of oral trazodone on the minimum alveolar concentration of isoflurane in dogs.

Author information

1
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
2
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. Electronic address: aarnes.1@osu.edu.

Abstract

OBJECTIVE:

To determine the effect of oral trazodone on the minimum alveolar concentration (MAC) of isoflurane in dogs.

STUDY DESIGN:

Prospective blinded, single-observer, randomized crossover experimental study.

ANIMALS:

Six adult (age 6.8 ± 1.6 months) healthy dogs (three males and three females), weighing 24.8 ± 3.4 kg (mean ± standard deviation).

METHODS:

Each dog was anesthetized twice with a minimum of 7 days between anesthetic episodes. Dogs were randomly assigned to be administered two treatments in a crossover design: premedication with trazodone (8 mg kg-1; TRAZ-ISO) orally 2 hours prior to an anesthetic episode or no (ISO). Dogs were anesthetized with intravenous propofol (6 mg kg-1) and isoflurane in >95% oxygen. Isoflurane MAC was determined using an iterative bracketing technique with electrodes placed in the buccal mucosa. Hemodynamic variables were compared at the lowest end-tidal isoflurane concentration at which each dog did not respond. A paired t test was used to assess the effect of treatment on outcome variables with significance set to a value of p < 0.05.

RESULTS:

The MAC concentration (mean ± standard deviation) in dogs administered TRAZ-ISO was 0.85 ± 0.17% compared with 1.02 ± 0.11% in those administered ISO (p = 0.01, 95% confidence interval -0.25 to -0.05), resulting in a mean MAC reduction of 17 ± 12%. There were no differences in hemodynamic variables between treatments.

CONCLUSIONS AND CLINICAL RELEVANCE:

Premedication of dogs with oral trazodone (8 mg kg-1) 2 hours prior to anesthetic induction has a significant isoflurane MAC sparing effect with no significant observed hemodynamic benefit.

KEYWORDS:

anesthesia; dog; isoflurane; minimum alveolar concentration; trazodone

PMID:
30297130
DOI:
10.1016/j.vaa.2018.08.002
[Indexed for MEDLINE]

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