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Clin Chim Acta. 2018 Oct 5. pii: S0009-8981(18)30536-9. doi: 10.1016/j.cca.2018.10.010. [Epub ahead of print]

Plasma metabolomic profiling distinguishes right-sided from left-sided colon cancer.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
2
Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150086, China.
3
Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin 150086, China.
4
Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: 13351112888@163.com.
5
Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China. Electronic address: likang@ems.hrbmu.edu.cn.

Abstract

BACKGROUND:

Many studies have demonstrated that right-sided colon cancer (RCC) has a higher mortality rate and worse prognosis than left-sided colon cancer (LCC). However, the underlying biological mechanism that can account for these differences is unclear.

METHODS:

In this study, plasma metabolic profiles in 147 LCC patients and 105 RCC patients were systematically analyzed by the ultra high performance liquid chromatography quadruple time-of-flight mass spectrometry (UHPLC-QTOF/MS) platform in conjunction with univariate and multivariate statistical analysis.

RESULTS:

Metabolic signatures revealed considerable differences between patients with RCC and LCC, and clear separations were observed between the two groups in partial least-squares discriminant analysis score plots. In total, six metabolites were identified as potential metabolite markers for tumor location in RCC compared with LCC, including upregulated trimethylamine N-oxide and indoxyl sulfate, and downregulated anserine, L-targinine, gamma-glutamyl-gamma-aminobutyraldehyde and pyridoxal 5'-phosphate. These differences highlight that significant alternations occur in the pathways of methane metabolism, arginine and proline metabolism, histidine metabolism, beta-alanine metabolism and vitamin B6 metabolism in RCC compared with LCC.

CONCLUSIONS:

Identified biomarkers and metabolic pathways may facilate our understanding of the different mortality rates and prognoses between RCC and LCC.

KEYWORDS:

Colorectal cancer; Left-sided colon cancer; Metabolomics; Plasma; Right-sided colon cancer; Tumor location

PMID:
30296444
DOI:
10.1016/j.cca.2018.10.010

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