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CJEM. 2018 Oct 8:1-4. doi: 10.1017/cem.2018.440. [Epub ahead of print]

Methotrexate for the treatment of unruptured tubal ectopic pregnancy.

Author information

1
*Schwartz/Reisman Emergency Medicine Institute,Toronto,ON.
2
‡Department of Obstetrics and Gyneacology,University of Toronto,Toronto,ON.

Abstract

CLINICIAN'S CAPSULE What is known about the topic? Methotrexate is widely accepted as first-line treatment of non-ruptured ectopic pregnancy and may be considered for women with a suspected ectopic pregnancy. What did this study ask? What are the outcomes of pregnant women with suspected ectopic pregnancy who received methotrexate as first-line treatment? What did this study find? Of patients treated with methotrexate, 18% went on to require surgical management, with 11.2% having ruptured on surgical evaluation. Why does this study matter to clinicians? Emergency department (ED) clinicians must be aware of the risk of methotrexate failure and have a high index of suspicion for patients returning to the ED.

KEYWORDS:

ectopic pregnancy; methotrexate; patient outcomes

PMID:
30295218
DOI:
10.1017/cem.2018.440

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