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Int J Dermatol. 2019 Apr;58(4):449-455. doi: 10.1111/ijd.14262. Epub 2018 Oct 7.

Primary cutaneous lymphoma in Argentina: a report of a nationwide study of 416 patients.

Author information

1
Hospital Gral. de Agudos Dr. C. Argerich, Ciudad de Buenos Aires, Argentina.
2
Hospital Italiano de Buenos Aires, Ciudad de Buenos Aires, Argentina.
3
Hospital de Pediatría Prof. Dr. J.P. Garrahan, Ciudad de Buenos Aires, Argentina.
4
Hospital Gral. de Agudos Dr. J.M. Ramos Mejia, Ciudad de Buenos Aires, Argentina.
5
Academia Nacional de Medicina, Ciudad de Buenos Aires, Argentina.
6
Hospital Privado de Córdoba, Ciudad de Córdoba, Argentina.
7
Psoriahue, Ciudad de Buenos Aires, Argentina.
8
Policlínico Bancario, Ciudad de Buenos Aires, Argentina.

Abstract

BACKGROUND:

The aim of this study was to determine the relative frequency of primary cutaneous lymphoma (PCL) in Argentina according to the new World Health Organization (WHO)-European Organization for the Research and Treatment of Cancer (EORTC) classification system.

METHODS:

A total of 416 patients from 21 dermatology services were included during a 5-year period (2010-2015); these patients were classified using WHO-EORTC criteria.

RESULTS:

There were 231 (55.2%) males and 185 (44.8%) females; the male-to-female ratio was 1.35. The median age of the patients was 57 years (range, 0-90 years). Most patients were Caucasian (79%), and only 16% of patients were registered as Amerindian. Most patients (387/416, 93%) had cutaneous T-cell lymphoma (CTCL); 28 patients (6.7%) were diagnosed with cutaneous B-cell lymphoma (CBCL). The most frequent CTCL subtypes, in decreasing order of prevalence, were mycosis fungoides (MF), including its variants (75.7%); CD30+ primary cutaneous lymphoproliferative disorders (7.2%); and Sézary syndrome (SS) (3.1%). Cutaneous follicle center lymphoma was the most common CBCL subtype (2.9%). In the subset of patients ≤20 years of age, the most common condition was MF (57%), followed by extranodal NK-T nasal-type lymphoma (14%).

CONCLUSIONS:

This study revealed relatively higher rates of MF and lower rates of CBCL in Argentinean patients that have been reported in American and European countries.

PMID:
30294921
DOI:
10.1111/ijd.14262

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