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J Carcinog. 2018 Sep 25;17:4. doi: 10.4103/jcar.JCar_2_18. eCollection 2018.

A case-control study on the association of abdominal obesity and hypercholesterolemia with the risk of colorectal cancer.

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Department of Healthcare Professional, Faculty of Health & Life Sciences, Management and Science University, Selangor Darul Ehsan, Malaysia.
Faculty of Applied Sciences, Ucsi University, Kuala Lumpur, Malaysia.
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.



Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases.


The objective of this study was to determine the relationship between obesity and blood lipids with a risk of colorectal cancer (CRC).


Histologically confirmed CRC patients from five local hospitals were matched with cancer-free controls for age, gender, and ethnicity (n = 140: 280). The study participants underwent physical assessment for the presence of obesity and 10 mL of fasting blood was drawn for blood lipid analysis.


In this study, abdominal obesity significantly doubled the risk of CRC (adjusted odds ratio [AOR] =1.69, 95% confidence interval [CI] = 1-2.83). Hypercholesterolemia and low high-density lipoprotein cholesterol (HDL) increased the risk of CRC more than twofolds (AOR = 2.6, 95% CI = 1.7-3.9 and AOR = 3.8, 95% CI = 2.3-6.3, respectively). Abdominal obesity and hypercholesterolemia synergically doubled the risk of CRC (AOR = 2.0, 95% CI = 1-4). Low-HDL has shown no synergic association with other dyslipidemic states with an increased CRC risk.


Improving abdominal obesity, hypercholesterolemia, and low HDL may be a clinically relevant strategy to reduce the risk of CRC among Malaysians.


Abdominal obesity; colorectal cancer; hypercholesterolemia

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