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J Midlife Health. 2018 Jul-Sep;9(3):140-144. doi: 10.4103/jmh.JMH_80_18.

Diagnostic Utility of Endometrial Aspiration Cytology in Women with Abnormal Uterine Bleeding.

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Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
Department of Obstetrics and Gynecology, Government Medical College and Hospital, Chandigarh, India.



Abnormal uterine bleeding (AUB) is a common problem for which women seek gynecological consultation. Endometrial aspiration cytology (EAC) has emerged as a minimally invasive and cost-effective diagnostic procedure for screening the endometrial status of these patients that can aid in diagnosis in high-burden and resource-limited settings.


The study was conducted to evaluate the utility of EAC in women with AUB, and the cytological diagnosis was compared with the histopathology.

Materials and Methods:

A total of 100 patients presenting with AUB were subjected to EAC using a 4-mm Karman's cannula. Later, they also underwent endometrial dilation and curettage. The cytology smears were evaluated for architectural and cytomorphological features. The cytological diagnoses henceforth made were compared with the histopathological diagnosis to calculate sensitivity, specificity, and diagnostic accuracy of EAC.


EAC showed a sample adequacy of 89% viz a viz 90% for histopathology. EAC showed a sensitivity of 87.5% and 100% for diagnosing benign and malignant conditions, respectively. There was a good overall agreement between cytological and histopathological diagnosis (κ = 0.585).


EAC is an effective and minimally invasive procedure for the primary investigation of women with AUB.


Abnormal uterine bleeding; endometrial aspiration cytology; histopathology

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