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Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Sep 7;53(9):684-687. doi: 10.3760/cma.j.issn.1673-0860.2018.09.009.

[Clinical analysis of malignant salivary gland tumors of the larynx].

[Article in Chinese; Abstract available in Chinese from the publisher]

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Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.
Department of Pathology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.


in English, Chinese

Objective: To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. Methods: A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End Results: (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66.5 years old; 8 patients with adenoid cystic carcinoma, 4 with mucoepidermoid carcinoma and 2 with adenocarcinoma; supraglottic, glottic and 4 subglottic malignancies respectively accounting for 5, 5 and 4 cases; 8 cases treated with surgery, 5 with surgery and postoperative radiotherapy and/or chemotherapy, and 1 with radiotherapy alone. The 14 patients showed a three-year overall survival rate of 50.0% and a five-year overall survival rate of 42.9%, respectively in contrast with the rates of 67.1% and 59.8% in SEER database. Conclusions: The malignant salivary gland tumor of the larynx is rare and it is difficult to be diagnosed early. It is more likely to occour local recurrence and distant metastasis. Extensive surgical resection with postoperative radiotherapy is advocated.


Immunohistochemistry; Laryngeal neoplasms; Prognosis; Salivary gland neoplasms; Treatment

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