Format

Send to

Choose Destination
J Dairy Sci. 2018 Dec;101(12):10664-10674. doi: 10.3168/jds.2018-14758. Epub 2018 Oct 3.

Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose-induced oxidation in male Kuming mice.

Author information

1
College of Food Science, Southwest University, Chongqing 400715, P.R. China; Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
2
College of Food Science, Southwest University, Chongqing 400715, P.R. China.
3
College of Life Science and Technology, Southwest Minzu University, Chengdu 610041, P.R. China.
4
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China; College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, P.R. China. Electronic address: zhaoxin@cque.edu.cn.
5
Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, P.R. China. Electronic address: songjiale@glmc.edu.cn.

Abstract

We investigated in vitro and in vivo antioxidant activity of Lactobacillus paracasei ssp. paracasei YBJ01 (LPSP-YBJ01) isolated and identified from fermented yogurt. Strain LPSP-YBJ01 had stress tolerance against acidity, bile salt, and osmotic pressure. Five in vitro antioxidant assays were used to evaluate antioxidant activity of LPSP-YBJ01, which could scavenge free radicals (2,2-diphenyl-1-picrylhydrazyl and hydroxyl) and superoxide anion in vitro. In addition, strain LPSP-YBJ01 had stronger antilipid peroxidation activity and weak reducing power in vitro. We measured in vivo antioxidant activity of LPSP-YBJ01 in an oxidation mouse model induced by d-galactose injection. Strain LPSP-YBJ01 significantly increased serum superoxide dismutase (SOD), glutathione peroxidase, and total-antioxidant capability, and inhibited generation of malondialdehyde in a dose-dependent manner. In addition, strain LPSP-YBJ01 also increased the hepatic and splenic protein expressions of some antioxidant enzymes such as catalase, Cu/Zn-SOD, and Mn-SOD in mice treated with d-galactose. Thus, LPSP-YBJ01 had antioxidant activity in vitro and in vivo and may be a useful probiotic.

KEYWORDS:

Lactobacillus paracasei ssp. paracasei YBJ01; d-galactose; in vitro antioxidant; oxidation mice

PMID:
30292551
DOI:
10.3168/jds.2018-14758
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center