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Trends Mol Med. 2018 Nov;24(11):917-918. doi: 10.1016/j.molmed.2018.09.003. Epub 2018 Oct 3.

Senescent Cells Drive Frailty through Systemic Signals.

Author information

1
Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands.
2
Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands. Electronic address: p.l.j.dekeizer@umcutrecht.nl.

Abstract

Senescent cells drive ageing and the associated loss in health and lifespan. Whether this is mediated by systemic signalling remained unclear. Recently, Xu et al. [1] (Nat. Med. 2018;24:1246-1256) answered this question by injecting senescent cells into young mice and observing a long-lasting increase in frailty and mortality.

KEYWORDS:

SASP; ageing; cellular senescence; frailty; paracrine; systemic

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