Format

Send to

Choose Destination
Psychiatry Res Neuroimaging. 2018 Nov 30;281:117-122. doi: 10.1016/j.pscychresns.2018.05.003. Epub 2018 Oct 3.

Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder.

Author information

1
Institute of Human and Social Sciences, Kanazawa University, Kanazawa, Japan; Research Center for Child Mental Development, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.
2
Research Center for Child Mental Development, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan. Electronic address: mitsuruk@med.kanazawa-u.ac.jp.
3
Research Center for Child Mental Development, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.
4
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
5
Health Administration Center, University of Fukui, Fukui, Japan.
6
Research Center for Child Mental Development, University of Fukui, Japan.
7
Research Center for Child Mental Development, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan; Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.

Abstract

Autism spectrum disorders (ASDs) are neurodevelopmental conditions with impairments in social communication and interaction. Empathy is the ability to understand and share another person's inner life, and it is an essential process in social cognition, which is deficient in ASD. The mismatch field (MMF) has been used as a neurophysiological marker for the automatic detection of changes in auditory stimuli. In the present study, we focused on long-term changes in MMF evoked by an empathic voice and changes in the empathy quotient (EQ) in ASD during an 8-week clinical trial using oxytocin (OT). Ten males with ASD without intellectual disability participated in this pilot study. The results demonstrated a significant positive correlation between the change in the MMF amplitude in the auditory cortex (i.e., right banks of the superior sulcus) and the change in the EQ score during the 8-week clinical trial, whereas no significant change was observed in the MMF amplitude or EQ score after the administration period of OT. Although we cannot conclude that the observed relationships were caused by OT's effect or by natural changes, our results suggest that MMF evoked by social voice can be a state-dependent marker of empathic abilities in male adults with ASD.

KEYWORDS:

Autism spectrum disorder (ASD); Empathy quotients (EQ); Magnetic mismatch field (MMF)

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center