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Neurochem Int. 2018 Dec;121:114-124. doi: 10.1016/j.neuint.2018.10.003. Epub 2018 Oct 3.

Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice.

Author information

1
Department of Biochemistry, College of Medicine, Konyang University, Daejeon, 35365, Republic of Korea.
2
Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
3
Department of Pharmaceutical Science, Jungwon University, Geosan, Chungbuk, 28024, Republic of Korea.
4
Department of Nursing, College of Nursing, Jeju National University, Jeju-si, 63243, Republic of Korea. Electronic address: neoreva@hanmail.net.
5
Department of Biomedical Science, Jungwon University, Geosan, Chungbuk, 28024, Republic of Korea; Department of Nephrology, School of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea. Electronic address: kjj1021@naver.com.
6
Department of Biochemistry, College of Medicine, Konyang University, Daejeon, 35365, Republic of Korea. Electronic address: hominmoon@konyang.ac.kr.

Abstract

One of the pathological hallmarks of Alzheimer's disease (AD) is the abnormal aggregation of amyloid beta (Aβ) peptides. Uncaria rhynchophylla (UR), one of the Uncaria species, has long been used to treat neurodegenerative disease. In particular, it has been reported that UR inhibits aggregation of Aβ in vitro. However, little is known about the histological effects of UR treatment on Aβ pathology in AD animal models. In the present study, we investigated the effect of UR on Aβ aggregation, Aβ-mediated pathologies and adult hippocampal neurogenesis in the brain of 5XFAD mice. First, using the thioflavin T assay and amyloid staining, we demonstrated that UR treatment effectively inhibited Aβ aggregation and accumulation in the cortex and subiculum. Second, immunofluorescence staining showed that administration of UR attenuated gliosis and neurodegeneration in the subiculum and cortex. Third, UR treatment ameliorated impaired adult hippocampal neurogenesis. The present results indicate that UR significantly alleviates Aβ deposition and Aβ-mediated neuropathology in the brain in 5XFAD mice, suggesting the potency of UR as a preventive and therapeutic agent for AD.

KEYWORDS:

Adult hippocampal neurogenesis; Alzheimer's disease; Amyloid beta; Neurodegeneration; Neuroinflammation; Uncaria rhynchophylla

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