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J Control Release. 2018 Nov 10;289:158-170. doi: 10.1016/j.jconrel.2018.10.001. Epub 2018 Oct 2.

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery.

Author information

1
Danesh Pey Hadi Co., Health Technology Development Center, Urmia University of Medical Sciences, Urmia, Iran.
2
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
3
School of Nutrition and Dietetics, Acadia University, Wolfville, Nova Scotia, Canada.
4
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
5
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran.
6
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir.
7
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: majidinia2.m@umsu.ac.ir.

Abstract

Application of exosomes, natural nanoscale vesicles, as specific delivery vehicles has received considerable attention in recent past years. The presence of various adhesive proteins on the surface of these lipid bilayers, gives them the ability to interact with cellular membranes. Although the function of exosomes was not known for some time, further researches have suggested that they are effective in multiple cellular pathways, as well as pathogenesis of a broad range of diseases including neurodegenerative diseases, cardiovascular diseases, and more importantly, multiple human malignancies. As erstwhile research brought to light more aspects of exosomes' biogenesis and functions, researchers sought to benefit from their effects in therapeutic and diagnostic purposes. Gene therapy is one of these fields that has seen many endeavors made. The present review article looks at gene therapy and its latest advancements, structure and function of exosomes and their role as bio shuttles in various clinical contexts relating to gene therapy.

KEYWORDS:

Exosomes; Gene transferring; Vehicle; miRNA; siRNA

PMID:
30290245
DOI:
10.1016/j.jconrel.2018.10.001
[Indexed for MEDLINE]

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