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Cell Stem Cell. 2018 Oct 4;23(4):466-467. doi: 10.1016/j.stem.2018.09.015.

Taking on the Elephant in the Tissue Culture Room: iPSC Modeling for Sporadic ALS.

Author information

1
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA. Electronic address: brian.wainger@mgh.harvard.edu.
2
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA. Electronic address: clagier-tourenne@mgh.harvard.edu.

Abstract

Modeling ALS remains a major challenge since the vast majority of cases are sporadic. Recently in Nature Medicine, Fujimori et al. leverage genetic heterogeneity and define subgroups of iPSC-derived motor neurons using multiplex phenotypic profiles, and thus make substantial progress toward robust modeling of both familial and sporadic ALS.

PMID:
30290176
DOI:
10.1016/j.stem.2018.09.015

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