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Pharmacotherapy. 2018 Dec;38(12):1194-1204. doi: 10.1002/phar.2185. Epub 2018 Nov 15.

Omadacycline Enters the Ring: A New Antimicrobial Contender.

Author information

1
Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, Mississippi.
2
Division of Pharmacy Practice and Administrative Sciences, University of Cincinnati James L. Winkle College of Pharmacy, Cincinnati, Ohio.
3
Department of Pharmacy Services, University of Mississippi Medical Center, Jackson, Mississippi.
4
Department of Medicine, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi.

Abstract

Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and current progress with omadacycline in clinical trials. Omadacycline inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome at the tetracycline-binding site with an affinity similar to glycylcyclines. It is able to bypass older tetracycline resistance mechanisms and demonstrates activity against bacterial strains that are tetracycline resistant. In addition, omadacycline displays broad-spectrum activity against gram-positive organisms (including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci), gram-negative organisms, atypical organisms, and anaerobes. It has been evaluated against infections in adults both intravenously and orally. Dosage adjustments are not required for patients with renal impairment. Omadacycline displays a comparable efficacy and safety profile to standard-of-care agents, with the most common side effects observed being gastrointestinal. Currently available data for omadacycline suggest that this is a promising agent added to our antimicrobial armamentarium.

KEYWORDS:

Enterococcus ; Staphylococcus ; Streptococcus ; gram-negative; omadacycline; resistance

PMID:
30290000
DOI:
10.1002/phar.2185

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