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Regen Med. 2018 Oct;13(7):845-858. doi: 10.2217/rme-2018-0056. Epub 2018 Oct 5.

Mapping and driving the stem cell ecosystem.

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Department of Cell Biology & Human Anatomy, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.


The stem cell and regenerative medicine arena has become increasingly complicated in recent years with thousands of people involved. There are as many as a dozen or more main groups of stakeholders, who together may be viewed as one ecosystem that is now rapidly evolving. The nature of the ecosystem and its evolution have major implications for not just those within it, but also for medicine and society at large. Here, I describe this ecosystem and its evolution, as well as the negative impacts within the ecosystem of a constellation of hundreds of unproven for-profit clinics and related businesses. Finally, I propose approaches for how to positively influence and drive the future of the global stem cell ecosystem.


FDA; regenerative medicine; stem cell clinical trials; stem cell clinics; stem cell ecosystem; stem cells

[Indexed for MEDLINE]

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