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Angew Chem Int Ed Engl. 2018 Oct 5. doi: 10.1002/anie.201810617. [Epub ahead of print]

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Author information

1
UNITED KINGDOM.
2
GERMANY.
3
CANADA.
4
University of Oxford, Structural Genomics Consortium, NDMRB, Roosevelt Drive, OX3 7FZ, Oxford, UNITED KINGDOM.

Abstract

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Dysregulation of these modified lysine binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterisation of the first small molecule chemical probe, SGC-iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). SGC-iMLLT is a potent and selective inhibitor of MLLT1/3 - histone interactions. Excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains was observed. Furthermore, our probe displays cellular target engagement of MLLT1 and MLLT3. The first small molecule X-ray co-crystal structures with the MLLT1 YD are also reported. This first in class probe molecule can be used to understand MLLT1/3 associated biology and the therapeutic potential of small molecule YD inhibitors.

KEYWORDS:

AF9; ENL; YEATS; chemical probes; epigenetics

PMID:
30288907
DOI:
10.1002/anie.201810617

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