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Nutrients. 2018 Oct 4;10(10). pii: E1423. doi: 10.3390/nu10101423.

Effect of Resveratrol, a Dietary-Derived Polyphenol, on the Oxidative Stress and Polyol Pathway in the Lens of Rats with Streptozotocin-Induced Diabetes.

Author information

1
Department of Ophthalmology, University Clinical Center, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. lech.sedlak@gmail.com.
2
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. lech.sedlak@gmail.com.
3
Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland. wwojnar@sum.edu.pl.
4
Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland. mzych@sum.edu.pl.
5
Department of Ophthalmology, University Clinical Center, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. wpdorota@gmail.com.
6
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. wpdorota@gmail.com.
7
Department of Ophthalmology, University Clinical Center, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. emrowka@poczta.onet.pl.
8
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, 40-514 Katowice, Poland. emrowka@poczta.onet.pl.
9
Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland. isedlak@sum.edu.pl.

Abstract

Resveratrol is found in grapes, apples, blueberries, mulberries, peanuts, pistachios, plums and red wine. Resveratrol has been shown to possess antioxidative activity and a variety of preventive effects in models of many diseases. The aim of the study was to investigate if this substance may counteract the oxidative stress and polyol pathway in the lens of diabetic rats. The study was conducted on the rats with streptozotocin-induced type 1 diabetes. After the administration of resveratrol (10 and 20 mg/kg po for 4 weeks), the oxidative stress markers in the lens were evaluated: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, calcium, sulfhydryl group, advanced oxidation protein products, malonyldialdehyde, Total Oxidant Status and Total Antioxidant Reactivity. The obtained results indicate that the administration of resveratrol to the diabetic rats shows antioxidative properties. It is not a result of antiglycaemic activity but resveratrol probably directly affects the antioxidative system. Resveratrol did not affect the polyol pathway in the lens of diabetic rats. Our results may indirectly indicate benefits of consumption of foods as well as dietary supplements containing resveratrol in diminishing oxidative stress in lenses of individuals suffering from diabetes mellitus.

KEYWORDS:

diabetes; lens; oxidative stress; polyol pathway; rats; resveratrol; streptozotocin

PMID:
30287729
PMCID:
PMC6213334
DOI:
10.3390/nu10101423
[Indexed for MEDLINE]
Free PMC Article

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