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Reprod Biomed Online. 2018 Sep 15. pii: S1472-6483(18)30407-3. doi: 10.1016/j.rbmo.2018.08.013. [Epub ahead of print]

Serum anti-Müllerian hormone concentration before and after salpingectomy for ectopic pregnancy.

Author information

1
Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, DK-2650Hvidovre, Denmark. Electronic address: anna.garcia-alix.haugen.grynnerup.01@regionh.dk.
2
Department of Obstetrics and Gynaecology, Zealand University Hospital Roskilde, Sygehusvej 10, DK-4000Roskilde, Denmark.
3
Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, DK-2650Hvidovre, Denmark; Clinical Research Centre, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, HvidovreDK-2650, Denmark.
4
Department of Obstetrics and Gynaecology, Odense University Hospital, J. B. Winsløwsvej 4, Odense CDenmark, C DK-5000.
5
Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, DK-2650Hvidovre, Denmark.

Abstract

RESEARCH QUESTION:

Does salpingectomy for ectopic pregnancy affect the ovarian reserve measured by changes in pre- and post-operative levels of anti-Müllerian hormone (AMH)?

DESIGN:

This is a prospective observational multicentre study of 64 women treated with salpingectomy for an ectopic pregnancy. AMH was measured in serum samples collected at admission before salpingectomy and at follow-up (median time to follow-up [interquartile range] was 3 [3-4] months). Changes in serum AMH levels were investigated using Wilcoxon signed-rank test and the relationship between changes in AMH and age, time to follow-up, and pre-operative serum AMH level was investigated using linear regression analysis. The biological variation of AMH was also calculated.

RESULTS:

Serum AMH levels did not differ significantly before and after salpingectomy (median ∆AMH [follow-up value minus admission value] 0.40 pmol/l, interquartile range -2.0 to 4.0 pmol/l). ΔAMH was independent of age, time to follow-up and pre-operative serum AMH level. The intra-individual biological variation for AMH ranged from 12.1% to 26.3%, depending on time between the two samples.

CONCLUSIONS:

This is the first paired study to investigate serum AMH values before and after salpingectomy in an unselected population of women presenting with an ectopic pregnancy, including both patients who conceived naturally and following fertility treatment. It was found that salpingectomy for ectopic pregnancy had no short-term effect on serum AMH levels, and changes in AMH levels were independent of age, time to follow-up, and pre-operative serum AMH level. Furthermore, the study demonstrated a 6-month biological variation of AMH of less than 30%.

KEYWORDS:

Anti-Müllerian hormone; Ectopic pregnancy; Ovarian reserve; Salpingectomy; Tubal pregnancy

PMID:
30287173
DOI:
10.1016/j.rbmo.2018.08.013

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