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Chemosphere. 2018 Dec;212:1085-1094. doi: 10.1016/j.chemosphere.2018.09.014. Epub 2018 Sep 4.

Toxic responses of zebrafish (Danio rerio) to thallium and deltamethrin characterized in the electrocardiogram.

Author information

1
Institute of Environment and Ecology, Shandong Normal University, Ji'nan, 250014, People's Republic of China.
2
Institute of Environment and Ecology, Shandong Normal University, Ji'nan, 250014, People's Republic of China. Electronic address: zmren@sdnu.edu.cn.

Abstract

The electrocardiogram (ECG) has been widely used to objectively address the physical condition as an index of stress. Though a numerous accounts of investigations on aquatic organisms' ECGs have been made, differentiation of ECG parameters in responding to specific toxic chemicals has not been extensively studied. In this research, it is hypothesized that zebrafish (Danio rerio) ECG parameters would differently respond to different types of pollutants, a heavy metal, thallium (Tl, 0.10 and 13.00 μg/L) and an organic chemical, deltamethrin (DM, 0.52 and 2.00 μg/L). Based on the SOM training and statistical analyses, QRS complex could be specified as an indicator of Tl stress, while QT interval might be used to evaluate DM stress. Pearson correlation analysis indicated that QRS complex and QT interval were significantly associated with Tl stress (r = 0.854, p = 0.0002) and DM stress (r = 0.792, p = 0.001), respectively. QRS complex and QT interval had the highest R2, the minimum of SSE and the lowest AIC value in Tl and DM treatments, respectively. Bases on the current experimental results and previous reports, QRS complex and QT interval could be considered as a specific indicator of Tl and DM disturbances in the environment, respectively.

KEYWORDS:

Deltamethrin; Electrocardiogram; QRS complex; QT interval; Thallium; Zebrafish

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