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Saudi Med J. 2018 Oct;39(10):1023-1027. doi: 10.15537/smj.2018.10.22852.

Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy. A double-blind, randomized and controlled trial.

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Department of Urology, The First Hospital of Jilin University, Changchun, China. E-mail.


To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy. Methods: The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded. Results: Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects.  Conclusion: Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.

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