Send to

Choose Destination
Case Rep Gastroenterol. 2018 Aug 31;12(2):546-550. doi: 10.1159/000492209. eCollection 2018 May-Aug.

Lorazepam as a Cause of Drug-Induced Liver Injury.

Author information

Department of Internal Medicine, Uenohara Municipal Hospital, Uenohara-shi, Japan.
Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, Japan.
Internal Medicine and Gastroenterology, Kusabana Clinic, Tokyo, Japan.
Department of Gastroenterology, Ito Municipal Hospital, Shizuoka, Japan.
Department of Gastroenterology and Hepatology, Nerima-Hikarigaoka Hospital, Tokyo, Japan.


Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam, treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam.


Depression; Drug-induced liver injury; Lorazepam

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
Loading ...
Support Center