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J Neuropsychiatry Clin Neurosci. 2019 Winter;31(1):49-56. doi: 10.1176/appi.neuropsych.17120351. Epub 2018 Oct 4.

Resting-State Functional Connectivity of the Habenula in Mood Disorder Patients With and Without Suicide-Related Behaviors.

Author information

1
From the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).

Abstract

The habenula is a small midbrain structure that is important for brain signaling and learning from negative events. Thus, the habenula is strongly connected to both the reward system and motor regions. Increasing evidence suggests a role for the habenula in the etiology of psychiatric disorders, including mood and substance use disorders. However, no studies to date have investigated habenular resting-state functional connectivity (rsFC) in suicide-related behaviors (SB). The authors enrolled 123 individuals with major depressive disorder (MDD) or bipolar disorder and a history of suicide-related behaviors (SB+), 74 individuals with MDD or bipolar disorder and a history of suicidal ideation but no history of SB (SB-), and 75 healthy control subjects (HC). A seed-based approach was used to identify regions showing different rsFC with the habenula followed by region of interest to region of interest post hoc comparisons. Compared with both the SB- and HC groups, the SB+ group showed higher connectivity between the left habenula and the left parahippocampal gyrus, the right amygdala, and the right precentral and postcentral gyri. Patients with mood disorders displayed higher rsFC between the left habenula and left middle temporal gyrus, the left angular gyrus, and the left posterior cingulate cortex, as well as lower rsFC between the right habenula and the left thalamus, when compared with HCs. These findings suggest that the habenula is involved in the neural circuitry of suicide. The higher habenular rsFC found in the SB+ group may mediate a dysfunction in the mechanism that links the habenula with motor activity and contextual associative processing.

KEYWORDS:

Bipolar Disorder; Habenula; Major Depressive Disorder; Resting-State fMRI; Suicide

PMID:
30282513
PMCID:
PMC6697145
[Available on 2020-01-01]
DOI:
10.1176/appi.neuropsych.17120351
[Indexed for MEDLINE]

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