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Am J Perinatol. 2019 May;36(6):609-614. doi: 10.1055/s-0038-1672171. Epub 2018 Oct 3.

PaO2/FiO2 Ratio as Predictor of Mortality in Neonates with Meconium Aspiration Syndrome.

Author information

1
Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, University of Delhi, Delhi, India.

Abstract

OBJECTIVES:

 Partial arterial pressure of oxygen/fraction of oxygen in inspired air (PaO2/FiO2) ratio has been used as a predictor of outcome in some neonatal conditions, but has not been used in meconium aspiration syndrome (MAS). This study was conducted with the objective to study if the PaO2/FiO2 ratio of < 200 at 6, 12, and 24 hours of life can predict mortality in neonates with MAS.

STUDY DESIGN:

 Two hundred neonates with MAS were included in the study. PaO2/FiO2 ratio was calculated at 6, 12, and 24 hours of life. Sensitivity, specificity, predictive values, and likelihood ratio at cut-off < 200 to predict mortality was calculated.

RESULTS:

 PaO2/FiO2 ratio at cut-off of < 200 was found to predict mortality in neonates with MAS with 94.1% sensitivity and 96.6% specificity. It was also able to predict development of severe MAS.

CONCLUSION:

 PaO2/FiO2 at < 200 can predict all-cause mortality in neonates with MAS. It can be used as vital tool in identifying newborns at high risk, thus helping in focused care.

PMID:
30282105
DOI:
10.1055/s-0038-1672171

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