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Phytother Res. 2018 Dec;32(12):2376-2388. doi: 10.1002/ptr.6199. Epub 2018 Oct 3.

A systematic review on the neuroprotective perspectives of beta-caryophyllene.

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Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Department of Product Development, Gaco Pharmaceuticals Limited, Dhaka, Bangladesh.
Flinders University College of Medicine and Public Health, Bedford Park, 5042, Adelaide, Australia.
Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.
Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Department of Chemistry, University of Jordan, Amman, Jordan.
Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar, India.


Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study reviews published reports pertaining to the neuropharmacological activities of BCAR. Databases such as PubMed, Scopus, MedLine Plus, and Google Scholar with keywords "beta (β)-caryophyllene" and other neurological keywords were searched. Data were extracted by referring to articles with information about the dose or concentration/route of administration, test system, results and discussion, and proposed mechanism of action. A total of 545 research articles were recorded, and 41 experimental studies were included in this review, after application of exclusion criterion. Search results suggest that BCAR exhibits a protective role in a number of nervous system-related disorders including pain, anxiety, spasm, convulsion, depression, alcoholism, and Alzheimer's disease. Additionally, BCAR has local anesthetic-like activity, which could protect the nervous system from oxidative stress and inflammation and can act as an immunomodulatory agent. Most neurological activities of this natural product have been linked with the cannabinoid receptors (CBRs), especially the CB2R. This review suggests a possible application of BCAR as a neuroprotective agent.


anti-inflammatory; antioxidant; neuro-protection; phytocannabinoid

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