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Acta Ophthalmol. 2019 Mar;97(2):e308-e312. doi: 10.1111/aos.13890. Epub 2018 Oct 2.

Retinal oxygen saturation as a non-invasive estimate for mixed venous oxygen saturation and cardiac output.

Author information

1
Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
2
Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
3
Department of Cardiology, University Hospitals Leuven, Leuven, Belgium.
4
Department of Ophthalmology, Centro Hospitalar São João, Porto, Portugal.
5
I-BioStat, KU Leuven, Leuven, Belgium.
6
Department of Ophthalmology, Lisbon North Hospital Centre, Lisbon, Portugal.

Abstract

PURPOSE:

To investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO2-mixed ) and cardiac output (CO).

METHODS:

Retinal arterial (SaO2-retinal ) and venous (SvO2-retinal ) oxygen saturation were measured non-invasively with dual-wavelength retinal oximetry in subjects receiving invasive measurements of SvO2-mixed and CO through right heart catheterization. Correlations were analysed using Spearman's rank correlation coefficients and linear regression models.

RESULTS:

Fourteen patients (median age 62.7 years, range: 21-77) were included in the analysis. When adjusted for age, SvO2-retinal showed a positive correlation with SvO2-mixed (β = 0.80, p = 0.003). Retinal arteriovenous oxygen saturation difference was significantly correlated with the inverse of CO (Spearman's ρ = 0.59, p = 0.026).

CONCLUSION:

This pilot study provides proof of concept for the use of retinal oximetry as a non-invasive tool to assess systemic cardiovascular function.

KEYWORDS:

cardiac output; mixed venous oxygen saturation; retinal oximetry; systemic hemodynamics

PMID:
30280510
DOI:
10.1111/aos.13890
[Indexed for MEDLINE]

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