Format

Send to

Choose Destination
Nutrition. 2019 Feb;58:7-10. doi: 10.1016/j.nut.2018.06.015. Epub 2018 Jul 12.

Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.

Author information

1
Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, México. Electronic address: luis_simental81@hotmail.com.
2
Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, México.

Abstract

OBJECTIVES:

The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia.

METHODS:

Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100 mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alcohol intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400 mg/dL, low-density lipoprotein cholesterol levels ≥190 mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria.

RESULTS:

Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 versus 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 versus 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels.

CONCLUSION:

The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.

KEYWORDS:

Dyslipidemia; Lipid profile; Lipids; Randomized controlled trial; Resveratrol

PMID:
30278430
DOI:
10.1016/j.nut.2018.06.015

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center